25 Jan 2012:: We now have a new download site: www.OmicsExpress.com
25 May 2011:: SVA is published in Bioinformatics.
21 Mar 2011:: SVA V1.10 is released: Supports GRCh build 37/hg19;  Supports user annotation track in GFF3 or BED formats.
9 Sep 2010:: The characterization of twenty sequenced human genomes. [Article]
12 Jul 2010:: LabCorp Launches Interleukin 28B Polymorphism (IL28B) Genotype Test to Support Individualized Treatment Decisions for Patients with Hepatitis C Viral Infection.
17 Jun 2010:: Causal variants for metachondromatosis are identified.
[Article] [SVA screenshot]
[GenomeWeb: The Daily Scan]
18 Mar 2010:: SVA 1.02[beta] is released.
11 Mar 2010:: SVA 1.01[beta] is released with a command line tool.
8 Mar 2010:: A lite evaluation edition is released for Windows. Play with it on your laptop!
23 Jan 2010:: SVA 1.00[beta] is released.
DNA sequence information underpins genetic research, enabling discoveries of important biological or medical benefit ( Bentley et al. Nature 2008; 456:53-59 ). Compared with previous discovery strategies, a whole-genome sequencing study is no longer constrained by differing patterns of linkage disequilibrium ( Need and Goldstein, Trends in Genetics 2009;25(11):489-494 ), thus, in theory, is more possible to directly identify the genetic variants contributing to biological traits or medical outcomes.
The rapidly evolving high-throughput DNA sequencing technologies have now allowed the fast generation of large amount of sequence data for the purpose of performing such whole-genome sequencing studies, at a reasonable cost. S equence V ariant A nalyzer, or SVA , is a software tool that we have been developing to analyze the genetic variants identified from such studies.
SVA is designed for two specific aims:
(1) To annotate the biological functions of the identified genetic variants, visualize and organize them;
(2) To help find the genetic variants associated with or responsible for the biological traits or medical outcomes of interest.
a program designed to run on a LINUX platform, with a graphical user interface (GUI), meaning that the main functions of this program can be done with clicking buttons.
© 2011 Dongliang Ge, PhD.