A note on the example project:

To reduce the size of the example project for your accessing convenience, this example contains only part (chromosome X) of the real data generated from a project including 5 patients with type A hemophilia patients resistant to HIV infection and 5 control genomes. This project is funded by the The Bill & Melinda Gates Foundation to David Goldstein at Duke University Center for Human Genome Variation .

To further reduce the size of the example project, the coverage and quality score datasets (namely, the '.bco' files) were restricted to only one file (example.X.bco). The SVA .bco file contains the chromosome-wise read-depth and quality scores across the whole genome for each individual. Therefore this example project is only for demonstration and instruction purposes, although all the variant data together with their individual variant quality scores (other than the chromosome-wise coverage) are real. So please do not be surprised to see that the coverage plot in SVA Genome Browser displays the same coverage and quality scores for all the 10 subjects - this was intentionally done to reduce the project file size. In your own project, the .bco file should be separate for each chromosome and for each individual.

System requirements for loading the example project

1. You need about 3GB of RAM to load the example project with its genome browser data. But with this amount of RAM you can only load the pre-annotated dataset. You cannot perform a new annotation with this amount of RAM (see item 3 below).
2. You need about 0.8GB RAM to load the example project without its genome browser data, in which case you will be able to list the annotated variants, but cannot search genes in the SVA Genome Browser panel, or perform following analysis or listing functions.
3. You need about 10GB of RAM to re-annotate the example project on your machine, instead of directly loading the pre-annotated version.